diff --git a/source/blender/blenloader/intern/versioning_500.cc b/source/blender/blenloader/intern/versioning_500.cc
index 37af962d2b7..8c6e1fdea38 100644
--- a/source/blender/blenloader/intern/versioning_500.cc
+++ b/source/blender/blenloader/intern/versioning_500.cc
@@ -2448,6 +2448,19 @@ static void do_version_bokeh_blur_pixel_size(bNodeTree &node_tree, bNode &node)
   }
 }
 
+static bool window_has_sequence_editor_open(const wmWindow *win)
+{
+  bScreen *screen = WM_window_get_active_screen(win);
+  LISTBASE_FOREACH (ScrArea *, area, &screen->areabase) {
+    LISTBASE_FOREACH (SpaceLink *, sl, &area->spacedata) {
+      if (sl->spacetype == SPACE_SEQ) {
+        return true;
+      }
+    }
+  }
+  return false;
+}
+
 void do_versions_after_linking_500(FileData *fd, Main *bmain)
 {
   if (!MAIN_VERSION_FILE_ATLEAST(bmain, 500, 9)) {
@@ -2539,9 +2552,13 @@ void do_versions_after_linking_500(FileData *fd, Main *bmain)
   if (!MAIN_VERSION_FILE_ATLEAST(bmain, 500, 63)) {
     LISTBASE_FOREACH (wmWindowManager *, wm, &bmain->wm) {
       LISTBASE_FOREACH (wmWindow *, win, &wm->windows) {
-        Scene *scene = WM_window_get_active_scene(win);
-        WorkSpace *workspace = WM_window_get_active_workspace(win);
-        workspace->sequencer_scene = scene;
+        if (window_has_sequence_editor_open(win)) {
+          Scene *scene = WM_window_get_active_scene(win);
+          if (scene->ed != nullptr) {
+            WorkSpace *workspace = WM_window_get_active_workspace(win);
+            workspace->sequencer_scene = scene;
+          }
+        }
       }
     }
   }
diff --git a/tests/python/bl_blendfile_relationships.py b/tests/python/bl_blendfile_relationships.py
index c4859ec9660..5de8787ab3e 100644
--- a/tests/python/bl_blendfile_relationships.py
+++ b/tests/python/bl_blendfile_relationships.py
@@ -46,7 +46,7 @@ class TestBlendUserMap(TestBlendLibLinkHelper):
         expected_map = {
             bpy.data.images[0]: {bpy.data.materials[0]},
             bpy.data.materials[0]: {bpy.data.meshes[0]},
-            bpy.data.scenes[0]: {bpy.data.window_managers[0], bpy.data.workspaces['Layout']},
+            bpy.data.scenes[0]: {bpy.data.window_managers[0]},
             bpy.data.collections[0]: {bpy.data.scenes[0]},
             bpy.data.libraries[0]: set(),
             bpy.data.meshes[0]: {bpy.data.objects[0]},