diff --git a/source/blender/editors/screen/screen_edit.cc b/source/blender/editors/screen/screen_edit.cc
index eadd34579c6..887d4a2754f 100644
--- a/source/blender/editors/screen/screen_edit.cc
+++ b/source/blender/editors/screen/screen_edit.cc
@@ -660,6 +660,10 @@ static void region_cursor_set(wmWindow *win, bool swin_changed)
 {
   bScreen *screen = WM_window_get_active_screen(win);
 
+  /* Don't touch cursor if something else is controling it, like button handling. See #51739. */
+  if (win->grabcursor) {
+    return;
+  }
   ED_screen_areas_iter (win, screen, area) {
     LISTBASE_FOREACH (ARegion *, region, &area->regionbase) {
       if (region == screen->active_region) {