diff --git a/source/blender/blenkernel/intern/anim_sys.cc b/source/blender/blenkernel/intern/anim_sys.cc
index 345b94f4a47..73eaef3ffa8 100644
--- a/source/blender/blenkernel/intern/anim_sys.cc
+++ b/source/blender/blenkernel/intern/anim_sys.cc
@@ -4238,6 +4238,13 @@ void BKE_animsys_eval_driver(Depsgraph *depsgraph, ID *id, int driver_index, FCu
     fcu = static_cast<FCurve *>(BLI_findlink(&adt->drivers, driver_index));
   }
 
+  if (!fcu) {
+    /* Trying to evaluate a driver that does no longer exist. Potentially missing a call to
+     * DEG_relations_tag_update. */
+    BLI_assert_unreachable();
+    return;
+  }
+
   DEG_debug_print_eval_subdata_index(
       depsgraph, __func__, id->name, id, "fcu", fcu->rna_path, fcu, fcu->array_index);
 
diff --git a/source/blender/makesrna/intern/rna_pose.cc b/source/blender/makesrna/intern/rna_pose.cc
index a58cf6d0bf4..433a88a0f94 100644
--- a/source/blender/makesrna/intern/rna_pose.cc
+++ b/source/blender/makesrna/intern/rna_pose.cc
@@ -392,6 +392,7 @@ static void rna_PoseChannel_constraints_remove(
   con_ptr->invalidate();
 
   blender::ed::object::constraint_update(bmain, ob);
+  DEG_relations_tag_update(bmain);
 
   /* XXX(@ideasman42): is this really needed? */
   BKE_constraints_active_set(&pchan->constraints, nullptr);
diff --git a/tests/python/bl_animation_drivers.py b/tests/python/bl_animation_drivers.py
index bcf63d80ddb..6c81a60aa03 100644
--- a/tests/python/bl_animation_drivers.py
+++ b/tests/python/bl_animation_drivers.py
@@ -236,6 +236,11 @@ class SubDataDriverRemovalTest(AbstractEmptyDriverTest, unittest.TestCase):
         self.assertEqual(len(pose_bone.constraints), 1)
         arm_ob.driver_add('pose.bones["test"].constraints["test"].distance')
         self.assertEqual(len(arm_ob.animation_data.drivers), 1)
+
+        # To do a proper test, the depsgraph needs to be evaluated between adding
+        # the data and removing it. This causes depsgraph nodes to be built, which
+        # have to be removed as well. See #141243
+        bpy.context.evaluated_depsgraph_get()
         pose_bone.constraints.remove(constraint)
         self.assertEqual(len(pose_bone.constraints), 0)
         self.assertEqual(len(arm_ob.animation_data.drivers), 0,