diff --git a/release/datafiles/userdef/userdef_default_theme.c b/release/datafiles/userdef/userdef_default_theme.c
index d2480b073dc..5bdc41ebed3 100644
--- a/release/datafiles/userdef/userdef_default_theme.c
+++ b/release/datafiles/userdef/userdef_default_theme.c
@@ -289,7 +289,7 @@ const bTheme U_theme_default = {
   },
   .regions = {
     .asset_shelf = {
-      .back = RGBA(0x303030ff),
+      .back = RGBA(0x303030e6),
       .header_back = RGBA(0x1d1d1dff),
     },
     .channels = {
@@ -298,10 +298,10 @@ const bTheme U_theme_default = {
       .text_selected = RGBA(0xffaf23ff),
     },
     .scrubbing = {
-      .back = RGBA(0x161616ff),
-      .text = RGBA(0xc3c3c3ff),
-      .time_marker = RGBA(0xffffff4d),
-      .time_marker_selected = RGBA(0xffffffb3),
+      .back = RGBA(0x1d1d1dff),
+      .text = RGBA(0x808080ff),
+      .time_marker = RGBA(0xffffff80),
+      .time_marker_selected = RGBA(0xffffffff),
     },
     .sidebars = {
       .back = RGBA(0x30303000),
@@ -312,7 +312,6 @@ const bTheme U_theme_default = {
     .anim = {
       .playhead = RGBA(0x4772b3ff),
       .preview_range = RGBA(0xa14d0066),
-      .scene_strip_range = RGBA(0x00000080),
       .channels = RGBA(0x194e8080),
       .channels_sub = RGBA(0x0f2c4d80),
       .channel_group = RGBA(0x1a332d37),
@@ -333,6 +332,7 @@ const bTheme U_theme_default = {
       .keyframe_generated_selected = RGBA(0xa28962ff),
       .long_key = RGBA(0xffffff1f),
       .long_key_selected = RGBA(0xff8c0099),
+      .scene_strip_range = RGBA(0x00000080),
     },
     .curves = {
       .handle_free = RGBA(0x745900ff),
@@ -648,15 +648,15 @@ const bTheme U_theme_default = {
     .row_alternate = RGBA(0xffffff04),
   },
   .space_node = {
-    .back = RGBA(0x1d1d1d00),
+    .back = RGBA(0x1a1a1a00),
     .title = RGBA(0xeeeeeeff),
     .text = RGBA(0xe6e6e6ff),
     .text_hi = RGBA(0xffffffff),
-    .header = RGBA(0x1d1d1db3),
+    .header = RGBA(0x1a1a1ab3),
     .header_text = RGBA(0xeeeeeeff),
     .header_text_hi = RGBA(0xffffffff),
     .shade2 = RGBA(0x7f7f7f64),
-    .grid = RGBA(0x28282800),
+    .grid = RGBA(0x30303000),
     .wire = RGBA(0x1a1a1aff),
     .select = RGBA(0xed5700ff),
     .active = RGBA(0xffffffff),
diff --git a/source/blender/blenloader/intern/versioning_userdef.cc b/source/blender/blenloader/intern/versioning_userdef.cc
index a2aaebab74f..676d2c80a9c 100644
--- a/source/blender/blenloader/intern/versioning_userdef.cc
+++ b/source/blender/blenloader/intern/versioning_userdef.cc
@@ -390,6 +390,26 @@ static void do_versions_theme(const UserDef *userdef, bTheme *btheme)
     FROM_DEFAULT_V4_UCHAR(common.anim.scene_strip_range);
   }
 
+  /* Reset the theme due to compatibility breaking changes in 5.0. */
+  if (!USER_VERSION_ATLEAST(500, 111)) {
+    MEMCPY_STRUCT_AFTER(btheme, &U_theme_default, name);
+    /* Update text styles to match. */
+    LISTBASE_FOREACH (uiStyle *, style, &userdef->uistyles) {
+      style->paneltitle.points = 11.0f;
+      style->paneltitle.shadow = 3;
+      style->paneltitle.shadowalpha = 0.5f;
+      style->paneltitle.shadowcolor = 0.0f;
+      style->widget.points = 11.0f;
+      style->widget.shadow = 1;
+      style->widget.shadowalpha = 0.5f;
+      style->widget.shadowcolor = 0.0f;
+      style->tooltip.shadow = 1;
+      style->tooltip.points = 11.0f;
+      style->tooltip.shadowalpha = 0.5f;
+      style->tooltip.shadowcolor = 0.0f;
+    }
+  }
+
   if (!USER_VERSION_ATLEAST(501, 3)) {
     FROM_DEFAULT_V4_UCHAR(space_action.anim_interpolation_other);
     FROM_DEFAULT_V4_UCHAR(space_action.anim_interpolation_constant);