diff --git a/source/blender/blenkernel/BKE_animsys.h b/source/blender/blenkernel/BKE_animsys.h
index 0825dd5c839..f28326b12e7 100644
--- a/source/blender/blenkernel/BKE_animsys.h
+++ b/source/blender/blenkernel/BKE_animsys.h
@@ -187,6 +187,25 @@ void BKE_animdata_fix_paths_rename_all(struct ID *ref_id,
  */
 bool BKE_animdata_fix_paths_remove(struct ID *id, const char *prefix);
 
+/**
+ * Remove drivers that have an RNA path starting with `prefix`.
+ *
+ * \return true if any driver was removed.
+ */
+bool BKE_animdata_driver_path_remove(struct ID *id, const char *prefix);
+
+/**
+ * Remove all drivers from the given struct.
+ *
+ * \param type needs to be a struct owned by the given ID.
+ * \param data the actual struct data, needs to be the data for the StructRNA.
+ *
+ * \return true if any driver was removed.
+ */
+bool BKE_animdata_drivers_remove_for_rna_struct(struct ID &owner_id,
+                                                struct StructRNA &type,
+                                                void *data);
+
 /* -------------------------------------- */
 
 typedef struct AnimationBasePathChange {
diff --git a/source/blender/blenkernel/BKE_constraint.h b/source/blender/blenkernel/BKE_constraint.h
index d8f8e82e51e..835e68c9678 100644
--- a/source/blender/blenkernel/BKE_constraint.h
+++ b/source/blender/blenkernel/BKE_constraint.h
@@ -243,11 +243,10 @@ struct bConstraint *BKE_constraint_add_for_pose(struct Object *ob,
                                                 const char *name,
                                                 short type);
 
-bool BKE_constraint_remove_ex(ListBase *list, struct Object *ob, struct bConstraint *con);
 /**
  * Remove the specified constraint from the given constraint stack.
  */
-bool BKE_constraint_remove(ListBase *list, struct bConstraint *con);
+bool BKE_constraint_remove_ex(ListBase *list, struct Object *ob, struct bConstraint *con);
 
 /**
  * Apply the specified constraint in the given constraint stack.
diff --git a/source/blender/blenkernel/intern/anim_data.cc b/source/blender/blenkernel/intern/anim_data.cc
index d57f55b2645..b8628fd7ce3 100644
--- a/source/blender/blenkernel/intern/anim_data.cc
+++ b/source/blender/blenkernel/intern/anim_data.cc
@@ -1216,6 +1216,29 @@ bool BKE_animdata_fix_paths_remove(ID *id, const char *prefix)
   return any_removed;
 }
 
+bool BKE_animdata_driver_path_remove(ID *id, const char *prefix)
+{
+  AnimData *adt = BKE_animdata_from_id(id);
+  if (!adt) {
+    return false;
+  }
+
+  const bool any_removed = fcurves_path_remove_from_listbase(prefix, &adt->drivers);
+  return any_removed;
+}
+
+bool BKE_animdata_drivers_remove_for_rna_struct(ID &owner_id, StructRNA &type, void *data)
+{
+  PointerRNA constraint_ptr = RNA_pointer_create_discrete(&owner_id, &type, data);
+  const std::optional<std::string> base_path = RNA_path_from_ID_to_struct(&constraint_ptr);
+  if (!base_path.has_value()) {
+    /* The data should exist, so the path should always resolve. */
+    BLI_assert_unreachable();
+  }
+
+  return BKE_animdata_driver_path_remove(&owner_id, base_path.value().c_str());
+}
+
 /* Apply Op to All FCurves in Database --------------------------- */
 
 /* Helper for adt_apply_all_fcurves_cb() - Apply wrapped operator to list of F-Curves */
diff --git a/source/blender/blenkernel/intern/constraint.cc b/source/blender/blenkernel/intern/constraint.cc
index 29294c3082f..5131a257409 100644
--- a/source/blender/blenkernel/intern/constraint.cc
+++ b/source/blender/blenkernel/intern/constraint.cc
@@ -72,6 +72,8 @@
 
 #include "BIK_api.h"
 
+#include "RNA_prototypes.hh"
+
 #include "DEG_depsgraph.hh"
 #include "DEG_depsgraph_query.hh"
 
@@ -5728,7 +5730,7 @@ void BKE_constraints_free(ListBase *list)
   BKE_constraints_free_ex(list, true);
 }
 
-bool BKE_constraint_remove(ListBase *list, bConstraint *con)
+static bool constraint_remove(ListBase *list, bConstraint *con)
 {
   if (con) {
     BKE_constraint_free_data(con);
@@ -5741,8 +5743,10 @@ bool BKE_constraint_remove(ListBase *list, bConstraint *con)
 
 bool BKE_constraint_remove_ex(ListBase *list, Object *ob, bConstraint *con)
 {
+  BKE_animdata_drivers_remove_for_rna_struct(ob->id, RNA_Constraint, con);
+
   const short type = con->type;
-  if (BKE_constraint_remove(list, con)) {
+  if (constraint_remove(list, con)) {
     /* ITASC needs to be rebuilt once a constraint is removed #26920. */
     if (ELEM(type, CONSTRAINT_TYPE_KINEMATIC, CONSTRAINT_TYPE_SPLINEIK)) {
       BIK_clear_data(ob->pose);
diff --git a/source/blender/blenkernel/intern/object.cc b/source/blender/blenkernel/intern/object.cc
index 15691a16bf1..affbe95bb48 100644
--- a/source/blender/blenkernel/intern/object.cc
+++ b/source/blender/blenkernel/intern/object.cc
@@ -137,6 +137,8 @@
 
 #include "ANIM_action_legacy.hh"
 
+#include "RNA_prototypes.hh"
+
 #ifdef WITH_PYTHON
 #  include "BPY_extern.hh"
 #endif
@@ -4459,6 +4461,8 @@ bool BKE_object_shapekey_remove(Main *bmain, Object *ob, KeyBlock *kb)
     return false;
   }
 
+  BKE_animdata_drivers_remove_for_rna_struct(key->id, RNA_ShapeKey, kb);
+
   kb_index = BLI_findindex(&key->block, kb);
   BLI_assert(kb_index != -1);
 
diff --git a/source/blender/editors/object/object_constraint.cc b/source/blender/editors/object/object_constraint.cc
index 6855854d0b3..bfc6c4e5091 100644
--- a/source/blender/editors/object/object_constraint.cc
+++ b/source/blender/editors/object/object_constraint.cc
@@ -2759,7 +2759,7 @@ static int pose_ik_clear_exec(bContext *C, wmOperator * /*op*/)
     for (con = static_cast<bConstraint *>(pchan->constraints.first); con; con = next) {
       next = con->next;
       if (con->type == CONSTRAINT_TYPE_KINEMATIC) {
-        BKE_constraint_remove(&pchan->constraints, con);
+        BKE_constraint_remove_ex(&pchan->constraints, ob, con);
       }
     }
     pchan->constflag &= ~(PCHAN_HAS_IK | PCHAN_HAS_NO_TARGET);
diff --git a/source/blender/editors/object/object_modifier.cc b/source/blender/editors/object/object_modifier.cc
index 4feb6f03ce2..c31f383b526 100644
--- a/source/blender/editors/object/object_modifier.cc
+++ b/source/blender/editors/object/object_modifier.cc
@@ -384,6 +384,8 @@ static bool object_modifier_remove(
     ob->mode &= ~OB_MODE_PARTICLE_EDIT;
   }
 
+  BKE_animdata_drivers_remove_for_rna_struct(ob->id, RNA_Modifier, md);
+
   BKE_modifier_remove_from_list(ob, md);
   BKE_modifier_free(md);
   BKE_object_free_derived_caches(ob);
diff --git a/source/blender/editors/object/object_relations.cc b/source/blender/editors/object/object_relations.cc
index 436e8b6a672..7bab504f690 100644
--- a/source/blender/editors/object/object_relations.cc
+++ b/source/blender/editors/object/object_relations.cc
@@ -1199,7 +1199,7 @@ static int object_track_clear_exec(bContext *C, wmOperator *op)
                CONSTRAINT_TYPE_LOCKTRACK,
                CONSTRAINT_TYPE_DAMPTRACK))
       {
-        BKE_constraint_remove(&ob->constraints, con);
+        BKE_constraint_remove_ex(&ob->constraints, ob, con);
       }
     }
 
diff --git a/source/blender/makesrna/intern/rna_object.cc b/source/blender/makesrna/intern/rna_object.cc
index c6d1fc2f263..f440bf8ed6b 100644
--- a/source/blender/makesrna/intern/rna_object.cc
+++ b/source/blender/makesrna/intern/rna_object.cc
@@ -1630,7 +1630,7 @@ static void rna_Object_constraints_remove(Object *object,
     return;
   }
 
-  BKE_constraint_remove(&object->constraints, con);
+  BKE_constraint_remove_ex(&object->constraints, object, con);
   RNA_POINTER_INVALIDATE(con_ptr);
 
   blender::ed::object::constraint_update(bmain, object);
diff --git a/source/blender/makesrna/intern/rna_pose.cc b/source/blender/makesrna/intern/rna_pose.cc
index d04876511f8..8a11b4a1796 100644
--- a/source/blender/makesrna/intern/rna_pose.cc
+++ b/source/blender/makesrna/intern/rna_pose.cc
@@ -388,7 +388,7 @@ static void rna_PoseChannel_constraints_remove(
     return;
   }
 
-  BKE_constraint_remove(&pchan->constraints, con);
+  BKE_constraint_remove_ex(&pchan->constraints, ob, con);
   RNA_POINTER_INVALIDATE(con_ptr);
 
   blender::ed::object::constraint_update(bmain, ob);
diff --git a/tests/python/bl_animation_drivers.py b/tests/python/bl_animation_drivers.py
index c6414aeccc9..dc290efaa50 100644
--- a/tests/python/bl_animation_drivers.py
+++ b/tests/python/bl_animation_drivers.py
@@ -194,6 +194,68 @@ class ContextViewLayerDriverTest(AbstractEmptyDriverTest, unittest.TestCase):
         self.assertPropValue('test_fallback', 321)
 
 
+class SubDataDriverRemovalTest(AbstractEmptyDriverTest, unittest.TestCase):
+
+    def test_remove_object_modifier(self):
+        # Removing a modifier with a driver should also delete the driver
+        modifier = self.obj.modifiers.new("test", 'ARRAY')
+        # No animation data means no drivers.
+        self.assertEqual(self.obj.animation_data, None)
+        self.obj.driver_add('modifiers["test"].count')
+        self.assertEqual(len(self.obj.animation_data.drivers), 1)
+        self.obj.modifiers.remove(modifier)
+        self.assertEqual(len(self.obj.modifiers), 0)
+        self.assertEqual(len(self.obj.animation_data.drivers), 0,
+                         "Removing the modifier should remove the driver on it")
+
+    def test_remove_object_constraint(self):
+        # Using limit distance constraint because that has a property that can have a driver.
+        constraint = self.obj.constraints.new('LIMIT_DISTANCE')
+        constraint.name = "test"
+        # No animation data means no drivers.
+        self.assertEqual(self.obj.animation_data, None)
+        self.obj.driver_add('constraints["test"].distance')
+        self.assertEqual(len(self.obj.animation_data.drivers), 1)
+        self.obj.constraints.remove(constraint)
+        self.assertEqual(len(self.obj.constraints), 0)
+        self.assertEqual(len(self.obj.animation_data.drivers), 0,
+                         "Removing the constraint should remove the driver on it")
+
+    def test_remove_bone_constraint(self):
+        arm = bpy.data.armatures.new('Armature')
+        arm_ob = bpy.data.objects.new('ArmObject', arm)
+        bpy.context.scene.collection.objects.link(arm_ob)
+        bpy.context.view_layer.objects.active = arm_ob
+        bpy.ops.object.mode_set(mode='EDIT')
+        ebone = arm.edit_bones.new(name="test")
+        ebone.tail = (1, 0, 0)
+        bpy.ops.object.mode_set(mode='POSE')
+        pose_bone = arm_ob.pose.bones["test"]
+        constraint = pose_bone.constraints.new('LIMIT_DISTANCE')
+        constraint.name = "test"
+        self.assertEqual(len(pose_bone.constraints), 1)
+        arm_ob.driver_add('pose.bones["test"].constraints["test"].distance')
+        self.assertEqual(len(arm_ob.animation_data.drivers), 1)
+        pose_bone.constraints.remove(constraint)
+        self.assertEqual(len(pose_bone.constraints), 0)
+        self.assertEqual(len(arm_ob.animation_data.drivers), 0,
+                         "Removing the constraint should remove the driver on it")
+
+    def test_remove_shapekey(self):
+        self.obj.shape_key_add(name="base")
+        test_key = self.obj.shape_key_add(name="test")
+        # Due to the weirdness of shapekeys, this is an ID.
+        shape_key_id = self.obj.data.shape_keys
+        self.assertEqual(len(shape_key_id.key_blocks), 2)
+        shape_key_id.driver_add('key_blocks["test"].value')
+        self.assertEqual(len(shape_key_id.animation_data.drivers), 1)
+
+        self.obj.shape_key_remove(test_key)
+        self.assertEqual(len(shape_key_id.key_blocks), 1)
+        self.assertEqual(len(shape_key_id.animation_data.drivers), 0,
+                         "Removing the shape key should remove any driver on it")
+
+
 def main():
     global args
     import argparse