diff --git a/source/blender/windowmanager/intern/wm_event_system.cc b/source/blender/windowmanager/intern/wm_event_system.cc
index 16ff632932d..ef8119cb3aa 100644
--- a/source/blender/windowmanager/intern/wm_event_system.cc
+++ b/source/blender/windowmanager/intern/wm_event_system.cc
@@ -4981,8 +4981,21 @@ bool WM_event_handler_region_marker_poll(const wmWindow *win,
       break;
   }
 
+  /* Check for markers in the current scene, noting that the VSE uses a special sequencer scene. */
+  Scene *scene = WM_window_get_active_scene(win);
+
+  if (area->spacetype == SPACE_SEQ) {
+    WorkSpace *workspace = WM_window_get_active_workspace(win);
+    if (workspace && workspace->sequencer_scene) {
+      scene = workspace->sequencer_scene;
+    }
+    else {
+      return false;
+    }
+  }
+
   const ListBase *markers = ED_scene_markers_get_from_area(
-      WM_window_get_active_scene(win), WM_window_get_active_view_layer(win), area);
+      scene, WM_window_get_active_view_layer(win), area);
   if (BLI_listbase_is_empty(markers)) {
     return false;
   }