diff --git a/scripts/modules/bpy/utils/__init__.py b/scripts/modules/bpy/utils/__init__.py
index da6aff8163e..f13feb12c12 100644
--- a/scripts/modules/bpy/utils/__init__.py
+++ b/scripts/modules/bpy/utils/__init__.py
@@ -285,6 +285,13 @@ def load_scripts(*, reload_scripts=False, refresh_scripts=False):
 
         del _global_loaded_modules[:]
 
+        # Update key-maps to account for operators no longer existing.
+        # Typically unloading operators would refresh the event system (such as disabling an add-on)
+        # however reloading scripts re-enable all add-ons immediately (which may inspect key-maps).
+        # For this reason it's important to update key-maps which will have been tagged to update.
+        # Without this, add-on register functions accessing key-map properties can crash, see: #111702.
+        _bpy.context.window_manager.keyconfigs.update()
+
     from bpy_restrict_state import RestrictBlend
 
     with RestrictBlend():