diff --git a/source/blender/gpu/intern/gpu_shader_builtin.cc b/source/blender/gpu/intern/gpu_shader_builtin.cc
index b960fc4d4d6..4135c61046d 100644
--- a/source/blender/gpu/intern/gpu_shader_builtin.cc
+++ b/source/blender/gpu/intern/gpu_shader_builtin.cc
@@ -6,6 +6,7 @@
  * \ingroup gpu
  */
 
+#include "BKE_global.hh"
 #include "BLI_utildefines.h"
 
 #include "GPU_capabilities.hh"
@@ -236,6 +237,12 @@ GPUShader *GPU_shader_get_builtin_shader(eGPUBuiltinShader shader)
 
 void GPU_shader_builtin_warm_up()
 {
+  if ((G.debug & G_DEBUG_GPU) && (GPU_backend_get_type() == GPU_BACKEND_OPENGL)) {
+    /* On some system (Mesa OpenGL), doing this warm up seems to breaks something related to debug
+     * hooks and makes the Blender application hang. */
+    return;
+  }
+
   if (GPU_use_subprocess_compilation() && (GPU_backend_get_type() == GPU_BACKEND_OPENGL)) {
     /* The overhead of creating the subprocesses at this exact moment can create bubbles during the
      * startup process. It is usually fast enough on OpenGL that we can skip it. */