diff --git a/intern/cycles/CMakeLists.txt b/intern/cycles/CMakeLists.txt
index 53e87fc5c3a..366d38cc94c 100644
--- a/intern/cycles/CMakeLists.txt
+++ b/intern/cycles/CMakeLists.txt
@@ -85,15 +85,11 @@ elseif(WIN32 AND MSVC AND NOT CMAKE_CXX_COMPILER_ID MATCHES "Clang")
   # there is no /arch:SSE3, but intrinsics are available anyway
   if(CMAKE_CL_64)
     set(CYCLES_SSE2_KERNEL_FLAGS "${CYCLES_KERNEL_FLAGS}")
-    set(CYCLES_SSE3_KERNEL_FLAGS "${CYCLES_KERNEL_FLAGS}")
     set(CYCLES_SSE41_KERNEL_FLAGS "${CYCLES_KERNEL_FLAGS}")
-    set(CYCLES_AVX_KERNEL_FLAGS "${CYCLES_AVX_ARCH_FLAGS} ${CYCLES_KERNEL_FLAGS}")
     set(CYCLES_AVX2_KERNEL_FLAGS "${CYCLES_AVX2_ARCH_FLAGS} ${CYCLES_KERNEL_FLAGS}")
   else()
     set(CYCLES_SSE2_KERNEL_FLAGS "/arch:SSE2 ${CYCLES_KERNEL_FLAGS}")
-    set(CYCLES_SSE3_KERNEL_FLAGS "/arch:SSE2 ${CYCLES_KERNEL_FLAGS}")
     set(CYCLES_SSE41_KERNEL_FLAGS "/arch:SSE2 ${CYCLES_KERNEL_FLAGS}")
-    set(CYCLES_AVX_KERNEL_FLAGS "${CYCLES_AVX_ARCH_FLAGS} ${CYCLES_KERNEL_FLAGS}")
     set(CYCLES_AVX2_KERNEL_FLAGS "${CYCLES_AVX2_ARCH_FLAGS} ${CYCLES_KERNEL_FLAGS}")
   endif()
 
@@ -126,11 +122,7 @@ elseif(CMAKE_COMPILER_IS_GNUCC OR (CMAKE_CXX_COMPILER_ID MATCHES "Clang"))
     endif()
 
     set(CYCLES_SSE2_KERNEL_FLAGS "${CYCLES_KERNEL_FLAGS} -msse -msse2")
-    set(CYCLES_SSE3_KERNEL_FLAGS "${CYCLES_SSE2_KERNEL_FLAGS} -msse3 -mssse3")
-    set(CYCLES_SSE41_KERNEL_FLAGS "${CYCLES_SSE3_KERNEL_FLAGS} -msse4.1")
-    if(CXX_HAS_AVX)
-      set(CYCLES_AVX_KERNEL_FLAGS "${CYCLES_SSE41_KERNEL_FLAGS} -mavx")
-    endif()
+    set(CYCLES_SSE41_KERNEL_FLAGS "${CYCLES_SSE2_KERNEL_FLAGS} -msse3 -mssse3 -msse4.1")
     if(CXX_HAS_AVX2)
       set(CYCLES_AVX2_KERNEL_FLAGS "${CYCLES_SSE41_KERNEL_FLAGS} -mavx -mavx2 -mfma -mlzcnt -mbmi -mbmi2 -mf16c")
     endif()
@@ -144,13 +136,8 @@ elseif(WIN32 AND CMAKE_CXX_COMPILER_ID MATCHES "Intel")
 
   if(CXX_HAS_SSE)
     set(CYCLES_SSE2_KERNEL_FLAGS "/QxSSE2")
-    set(CYCLES_SSE3_KERNEL_FLAGS "/QxSSSE3")
     set(CYCLES_SSE41_KERNEL_FLAGS "/QxSSE4.1")
 
-    if(CXX_HAS_AVX)
-      set(CYCLES_AVX_KERNEL_FLAGS "/arch:AVX")
-    endif()
-
     if(CXX_HAS_AVX2)
       set(CYCLES_AVX2_KERNEL_FLAGS "/QxCORE-AVX2")
     endif()
@@ -174,13 +161,8 @@ elseif(CMAKE_CXX_COMPILER_ID MATCHES "Intel")
       set(CYCLES_SSE2_KERNEL_FLAGS "-xsse2")
     endif()
 
-    set(CYCLES_SSE3_KERNEL_FLAGS "-xssse3")
     set(CYCLES_SSE41_KERNEL_FLAGS "-xsse4.1")
 
-    if(CXX_HAS_AVX)
-      set(CYCLES_AVX_KERNEL_FLAGS "-xavx")
-    endif()
-
     if(CXX_HAS_AVX2)
       set(CYCLES_AVX2_KERNEL_FLAGS "-xcore-avx2")
     endif()
@@ -190,15 +172,10 @@ endif()
 if(CXX_HAS_SSE)
   add_definitions(
     -DWITH_KERNEL_SSE2
-    -DWITH_KERNEL_SSE3
     -DWITH_KERNEL_SSE41
   )
 endif()
 
-if(CXX_HAS_AVX)
-  add_definitions(-DWITH_KERNEL_AVX)
-endif()
-
 if(CXX_HAS_AVX2)
   add_definitions(-DWITH_KERNEL_AVX2)
 endif()
diff --git a/intern/cycles/blender/addon/properties.py b/intern/cycles/blender/addon/properties.py
index 9ec663eb258..9c1cb0a1b4a 100644
--- a/intern/cycles/blender/addon/properties.py
+++ b/intern/cycles/blender/addon/properties.py
@@ -951,9 +951,7 @@ class CyclesRenderSettings(bpy.types.PropertyGroup):
         return _cycles.debug_flags_update(scene)
 
     debug_use_cpu_avx2: BoolProperty(name="AVX2", default=True)
-    debug_use_cpu_avx: BoolProperty(name="AVX", default=True)
     debug_use_cpu_sse41: BoolProperty(name="SSE41", default=True)
-    debug_use_cpu_sse3: BoolProperty(name="SSE3", default=True)
     debug_use_cpu_sse2: BoolProperty(name="SSE2", default=True)
     debug_bvh_layout: EnumProperty(
         name="BVH Layout",
diff --git a/intern/cycles/blender/addon/ui.py b/intern/cycles/blender/addon/ui.py
index 102e014297f..81f940529d1 100644
--- a/intern/cycles/blender/addon/ui.py
+++ b/intern/cycles/blender/addon/ui.py
@@ -2112,9 +2112,7 @@ class CYCLES_RENDER_PT_debug(CyclesDebugButtonsPanel, Panel):
 
         row = col.row(align=True)
         row.prop(cscene, "debug_use_cpu_sse2", toggle=True)
-        row.prop(cscene, "debug_use_cpu_sse3", toggle=True)
         row.prop(cscene, "debug_use_cpu_sse41", toggle=True)
-        row.prop(cscene, "debug_use_cpu_avx", toggle=True)
         row.prop(cscene, "debug_use_cpu_avx2", toggle=True)
         col.prop(cscene, "debug_bvh_layout", text="BVH")
 
diff --git a/intern/cycles/blender/python.cpp b/intern/cycles/blender/python.cpp
index 96cb204be4b..ebbdc8abf7f 100644
--- a/intern/cycles/blender/python.cpp
+++ b/intern/cycles/blender/python.cpp
@@ -63,9 +63,7 @@ static void debug_flags_sync_from_scene(BL::Scene b_scene)
   PointerRNA cscene = RNA_pointer_get(&b_scene.ptr, "cycles");
   /* Synchronize CPU flags. */
   flags.cpu.avx2 = get_boolean(cscene, "debug_use_cpu_avx2");
-  flags.cpu.avx = get_boolean(cscene, "debug_use_cpu_avx");
   flags.cpu.sse41 = get_boolean(cscene, "debug_use_cpu_sse41");
-  flags.cpu.sse3 = get_boolean(cscene, "debug_use_cpu_sse3");
   flags.cpu.sse2 = get_boolean(cscene, "debug_use_cpu_sse2");
   flags.cpu.bvh_layout = (BVHLayout)get_enum(cscene, "debug_bvh_layout");
   /* Synchronize CUDA flags. */
diff --git a/intern/cycles/device/cpu/device.cpp b/intern/cycles/device/cpu/device.cpp
index 9b249063aec..580f70b25d7 100644
--- a/intern/cycles/device/cpu/device.cpp
+++ b/intern/cycles/device/cpu/device.cpp
@@ -45,9 +45,7 @@ string device_cpu_capabilities()
 {
   string capabilities = "";
   capabilities += system_cpu_support_sse2() ? "SSE2 " : "";
-  capabilities += system_cpu_support_sse3() ? "SSE3 " : "";
   capabilities += system_cpu_support_sse41() ? "SSE41 " : "";
-  capabilities += system_cpu_support_avx() ? "AVX " : "";
   capabilities += system_cpu_support_avx2() ? "AVX2" : "";
   if (capabilities[capabilities.size() - 1] == ' ')
     capabilities.resize(capabilities.size() - 1);
diff --git a/intern/cycles/device/cpu/kernel.cpp b/intern/cycles/device/cpu/kernel.cpp
index 3e078129bca..4ca68e875a3 100644
--- a/intern/cycles/device/cpu/kernel.cpp
+++ b/intern/cycles/device/cpu/kernel.cpp
@@ -9,8 +9,7 @@ CCL_NAMESPACE_BEGIN
 
 #define KERNEL_FUNCTIONS(name) \
   KERNEL_NAME_EVAL(cpu, name), KERNEL_NAME_EVAL(cpu_sse2, name), \
-      KERNEL_NAME_EVAL(cpu_sse3, name), KERNEL_NAME_EVAL(cpu_sse41, name), \
-      KERNEL_NAME_EVAL(cpu_avx, name), KERNEL_NAME_EVAL(cpu_avx2, name)
+      KERNEL_NAME_EVAL(cpu_sse41, name), KERNEL_NAME_EVAL(cpu_avx2, name)
 
 #define REGISTER_KERNEL(name) name(KERNEL_FUNCTIONS(name))
 #define REGISTER_KERNEL_FILM_CONVERT(name) \
diff --git a/intern/cycles/device/cpu/kernel_function.h b/intern/cycles/device/cpu/kernel_function.h
index 6171f582518..4875f66f8a8 100644
--- a/intern/cycles/device/cpu/kernel_function.h
+++ b/intern/cycles/device/cpu/kernel_function.h
@@ -17,13 +17,10 @@ template<typename FunctionType> class CPUKernelFunction {
  public:
   CPUKernelFunction(FunctionType kernel_default,
                     FunctionType kernel_sse2,
-                    FunctionType kernel_sse3,
                     FunctionType kernel_sse41,
-                    FunctionType kernel_avx,
                     FunctionType kernel_avx2)
   {
-    kernel_info_ = get_best_kernel_info(
-        kernel_default, kernel_sse2, kernel_sse3, kernel_sse41, kernel_avx, kernel_avx2);
+    kernel_info_ = get_best_kernel_info(kernel_default, kernel_sse2, kernel_sse41, kernel_avx2);
   }
 
   template<typename... Args> inline auto operator()(Args... args) const
@@ -60,16 +57,12 @@ template<typename FunctionType> class CPUKernelFunction {
 
   KernelInfo get_best_kernel_info(FunctionType kernel_default,
                                   FunctionType kernel_sse2,
-                                  FunctionType kernel_sse3,
                                   FunctionType kernel_sse41,
-                                  FunctionType kernel_avx,
                                   FunctionType kernel_avx2)
   {
     /* Silence warnings about unused variables when compiling without some architectures. */
     (void)kernel_sse2;
-    (void)kernel_sse3;
     (void)kernel_sse41;
-    (void)kernel_avx;
     (void)kernel_avx2;
 
 #ifdef WITH_CYCLES_OPTIMIZED_KERNEL_AVX2
@@ -78,24 +71,12 @@ template<typename FunctionType> class CPUKernelFunction {
     }
 #endif
 
-#ifdef WITH_CYCLES_OPTIMIZED_KERNEL_AVX
-    if (DebugFlags().cpu.has_avx() && system_cpu_support_avx()) {
-      return KernelInfo("AVX", kernel_avx);
-    }
-#endif
-
 #ifdef WITH_CYCLES_OPTIMIZED_KERNEL_SSE41
     if (DebugFlags().cpu.has_sse41() && system_cpu_support_sse41()) {
       return KernelInfo("SSE4.1", kernel_sse41);
     }
 #endif
 
-#ifdef WITH_CYCLES_OPTIMIZED_KERNEL_SSE3
-    if (DebugFlags().cpu.has_sse3() && system_cpu_support_sse3()) {
-      return KernelInfo("SSE3", kernel_sse3);
-    }
-#endif
-
 #ifdef WITH_CYCLES_OPTIMIZED_KERNEL_SSE2
     if (DebugFlags().cpu.has_sse2() && system_cpu_support_sse2()) {
       return KernelInfo("SSE2", kernel_sse2);
diff --git a/intern/cycles/kernel/CMakeLists.txt b/intern/cycles/kernel/CMakeLists.txt
index 5ba1b683d6b..3ae468efd1f 100644
--- a/intern/cycles/kernel/CMakeLists.txt
+++ b/intern/cycles/kernel/CMakeLists.txt
@@ -14,9 +14,7 @@ set(INC_SYS
 set(SRC_KERNEL_DEVICE_CPU
   device/cpu/kernel.cpp
   device/cpu/kernel_sse2.cpp
-  device/cpu/kernel_sse3.cpp
   device/cpu/kernel_sse41.cpp
-  device/cpu/kernel_avx.cpp
   device/cpu/kernel_avx2.cpp
 )
 
@@ -940,14 +938,9 @@ set_source_files_properties(device/cpu/kernel.cpp PROPERTIES COMPILE_FLAGS "${CY
 
 if(CXX_HAS_SSE)
   set_source_files_properties(device/cpu/kernel_sse2.cpp PROPERTIES COMPILE_FLAGS "${CYCLES_SSE2_KERNEL_FLAGS}")
-  set_source_files_properties(device/cpu/kernel_sse3.cpp PROPERTIES COMPILE_FLAGS "${CYCLES_SSE3_KERNEL_FLAGS}")
   set_source_files_properties(device/cpu/kernel_sse41.cpp PROPERTIES COMPILE_FLAGS "${CYCLES_SSE41_KERNEL_FLAGS}")
 endif()
 
-if(CXX_HAS_AVX)
-  set_source_files_properties(device/cpu/kernel_avx.cpp PROPERTIES COMPILE_FLAGS "${CYCLES_AVX_KERNEL_FLAGS}")
-endif()
-
 if(CXX_HAS_AVX2)
   set_source_files_properties(device/cpu/kernel_avx2.cpp PROPERTIES COMPILE_FLAGS "${CYCLES_AVX2_KERNEL_FLAGS}")
 endif()
diff --git a/intern/cycles/kernel/device/cpu/kernel.h b/intern/cycles/kernel/device/cpu/kernel.h
index 647b405140a..e43d7375eea 100644
--- a/intern/cycles/kernel/device/cpu/kernel.h
+++ b/intern/cycles/kernel/device/cpu/kernel.h
@@ -35,15 +35,9 @@ void kernel_global_memory_copy(KernelGlobalsCPU *kg, const char *name, void *mem
 #define KERNEL_ARCH cpu_sse2
 #include "kernel/device/cpu/kernel_arch.h"
 
-#define KERNEL_ARCH cpu_sse3
-#include "kernel/device/cpu/kernel_arch.h"
-
 #define KERNEL_ARCH cpu_sse41
 #include "kernel/device/cpu/kernel_arch.h"
 
-#define KERNEL_ARCH cpu_avx
-#include "kernel/device/cpu/kernel_arch.h"
-
 #define KERNEL_ARCH cpu_avx2
 #include "kernel/device/cpu/kernel_arch.h"
 
diff --git a/intern/cycles/kernel/device/cpu/kernel_avx.cpp b/intern/cycles/kernel/device/cpu/kernel_avx.cpp
deleted file mode 100644
index 872ad5ce7e2..00000000000
--- a/intern/cycles/kernel/device/cpu/kernel_avx.cpp
+++ /dev/null
@@ -1,26 +0,0 @@
-/* SPDX-License-Identifier: Apache-2.0
- * Copyright 2011-2022 Blender Foundation */
-
-/* Optimized CPU kernel entry points. This file is compiled with AVX
- * optimization flags and nearly all functions inlined, while kernel.cpp
- * is compiled without for other CPU's. */
-
-#include "util/optimization.h"
-
-#ifndef WITH_CYCLES_OPTIMIZED_KERNEL_AVX
-#  define KERNEL_STUB
-#else
-/* SSE optimization disabled for now on 32 bit, see bug T36316. */
-#  if !(defined(__GNUC__) && (defined(i386) || defined(_M_IX86)))
-#    define __KERNEL_SSE__
-#    define __KERNEL_SSE2__
-#    define __KERNEL_SSE3__
-#    define __KERNEL_SSSE3__
-#    define __KERNEL_SSE41__
-#    define __KERNEL_AVX__
-#  endif
-#endif /* WITH_CYCLES_OPTIMIZED_KERNEL_AVX */
-
-#include "kernel/device/cpu/kernel.h"
-#define KERNEL_ARCH cpu_avx
-#include "kernel/device/cpu/kernel_arch_impl.h"
diff --git a/intern/cycles/kernel/device/cpu/kernel_sse3.cpp b/intern/cycles/kernel/device/cpu/kernel_sse3.cpp
deleted file mode 100644
index eb78b61a723..00000000000
--- a/intern/cycles/kernel/device/cpu/kernel_sse3.cpp
+++ /dev/null
@@ -1,23 +0,0 @@
-/* SPDX-License-Identifier: Apache-2.0
- * Copyright 2011-2022 Blender Foundation */
-
-/* Optimized CPU kernel entry points. This file is compiled with SSE3/SSSE3
- * optimization flags and nearly all functions inlined, while kernel.cpp
- * is compiled without for other CPU's. */
-
-#include "util/optimization.h"
-
-#ifndef WITH_CYCLES_OPTIMIZED_KERNEL_SSE3
-#  define KERNEL_STUB
-#else
-/* SSE optimization disabled for now on 32 bit, see bug T36316. */
-#  if !(defined(__GNUC__) && (defined(i386) || defined(_M_IX86)))
-#    define __KERNEL_SSE2__
-#    define __KERNEL_SSE3__
-#    define __KERNEL_SSSE3__
-#  endif
-#endif /* WITH_CYCLES_OPTIMIZED_KERNEL_SSE3 */
-
-#include "kernel/device/cpu/kernel.h"
-#define KERNEL_ARCH cpu_sse3
-#include "kernel/device/cpu/kernel_arch_impl.h"
diff --git a/intern/cycles/test/CMakeLists.txt b/intern/cycles/test/CMakeLists.txt
index 34e5a4770ea..cdf8f7db0bb 100644
--- a/intern/cycles/test/CMakeLists.txt
+++ b/intern/cycles/test/CMakeLists.txt
@@ -45,19 +45,6 @@ set(SRC
 # Disable AVX tests on macOS. Rosetta has problems running them, and other
 # platforms should be enough to verify AVX operations are implemented correctly.
 if(NOT APPLE)
-  if(CXX_HAS_SSE)
-    list(APPEND SRC
-      util_float8_sse2_test.cpp
-    )
-    set_source_files_properties(util_float8_avx_test.cpp PROPERTIES COMPILE_FLAGS "${CYCLES_SSE2_KERNEL_FLAGS}")
-  endif()
-
-  if(CXX_HAS_AVX)
-    list(APPEND SRC
-      util_float8_avx_test.cpp
-    )
-    set_source_files_properties(util_float8_avx_test.cpp PROPERTIES COMPILE_FLAGS "${CYCLES_AVX_KERNEL_FLAGS}")
-  endif()
   if(CXX_HAS_AVX2)
     list(APPEND SRC
       util_float8_avx2_test.cpp
diff --git a/intern/cycles/util/debug.cpp b/intern/cycles/util/debug.cpp
index 8210e21f951..e7cf7b545b8 100644
--- a/intern/cycles/util/debug.cpp
+++ b/intern/cycles/util/debug.cpp
@@ -29,9 +29,7 @@ void DebugFlags::CPU::reset()
   } while (0)
 
   CHECK_CPU_FLAGS(avx2, "CYCLES_CPU_NO_AVX2");
-  CHECK_CPU_FLAGS(avx, "CYCLES_CPU_NO_AVX");
   CHECK_CPU_FLAGS(sse41, "CYCLES_CPU_NO_SSE41");
-  CHECK_CPU_FLAGS(sse3, "CYCLES_CPU_NO_SSE3");
   CHECK_CPU_FLAGS(sse2, "CYCLES_CPU_NO_SSE2");
 
 #undef STRINGIFY
diff --git a/intern/cycles/util/debug.h b/intern/cycles/util/debug.h
index ab200649f59..9ee09f08581 100644
--- a/intern/cycles/util/debug.h
+++ b/intern/cycles/util/debug.h
@@ -26,9 +26,7 @@ class DebugFlags {
 
     /* Flags describing which instructions sets are allowed for use. */
     bool avx2 = true;
-    bool avx = true;
     bool sse41 = true;
-    bool sse3 = true;
     bool sse2 = true;
 
     /* Check functions to see whether instructions up to the given one
@@ -36,19 +34,11 @@ class DebugFlags {
      */
     bool has_avx2()
     {
-      return has_avx() && avx2;
-    }
-    bool has_avx()
-    {
-      return has_sse41() && avx;
+      return has_sse41() && avx2;
     }
     bool has_sse41()
     {
-      return has_sse3() && sse41;
-    }
-    bool has_sse3()
-    {
-      return has_sse2() && sse3;
+      return has_sse2() && sse41;
     }
     bool has_sse2()
     {
diff --git a/intern/cycles/util/optimization.h b/intern/cycles/util/optimization.h
index 19b96510c47..b6194dc0382 100644
--- a/intern/cycles/util/optimization.h
+++ b/intern/cycles/util/optimization.h
@@ -17,9 +17,6 @@
 #    ifdef WITH_KERNEL_SSE2
 #      define WITH_CYCLES_OPTIMIZED_KERNEL_SSE2
 #    endif
-#    ifdef WITH_KERNEL_SSE3
-#      define WITH_CYCLES_OPTIMIZED_KERNEL_SSE3
-#    endif
 
 /* x86-64
  *
@@ -30,15 +27,9 @@
 /* SSE2 is always available on x86-64 CPUs, so auto enable */
 #    define __KERNEL_SSE2__
 /* no SSE2 kernel on x86-64, part of regular kernel */
-#    ifdef WITH_KERNEL_SSE3
-#      define WITH_CYCLES_OPTIMIZED_KERNEL_SSE3
-#    endif
 #    ifdef WITH_KERNEL_SSE41
 #      define WITH_CYCLES_OPTIMIZED_KERNEL_SSE41
 #    endif
-#    ifdef WITH_KERNEL_AVX
-#      define WITH_CYCLES_OPTIMIZED_KERNEL_AVX
-#    endif
 #    ifdef WITH_KERNEL_AVX2
 #      define WITH_CYCLES_OPTIMIZED_KERNEL_AVX2
 #    endif
diff --git a/intern/cycles/util/system.h b/intern/cycles/util/system.h
index 2152b89ed24..66140cabf84 100644
--- a/intern/cycles/util/system.h
+++ b/intern/cycles/util/system.h
@@ -17,9 +17,7 @@ int system_console_width();
 std::string system_cpu_brand_string();
 int system_cpu_bits();
 bool system_cpu_support_sse2();
-bool system_cpu_support_sse3();
 bool system_cpu_support_sse41();
-bool system_cpu_support_avx();
 bool system_cpu_support_avx2();
 
 size_t system_physical_ram();