diff --git a/scripts/startup/bl_ui/space_userpref.py b/scripts/startup/bl_ui/space_userpref.py
index 314509ba593..729498c0c8d 100644
--- a/scripts/startup/bl_ui/space_userpref.py
+++ b/scripts/startup/bl_ui/space_userpref.py
@@ -270,6 +270,19 @@ class USERPREF_PT_interface_translation(InterfacePanel, CenterAlignMixIn, Panel)
         col.prop(view, "use_translate_new_dataname", text="New Data")
 
 
+class USERPREF_PT_interface_accessibility(InterfacePanel, CenterAlignMixIn, Panel):
+    bl_label = "Accessibility"
+    bl_options = {'DEFAULT_CLOSED'}
+
+    def draw_centered(self, context, layout):
+        prefs = context.preferences
+        view = prefs.view
+
+        flow = layout.grid_flow(row_major=False, columns=0, even_columns=True, even_rows=False, align=False)
+
+        flow.prop(view, "use_reduce_motion")
+
+
 class USERPREF_PT_interface_editors(InterfacePanel, CenterAlignMixIn, Panel):
     bl_label = "Editors"
 
@@ -2954,6 +2967,7 @@ classes = (
     USERPREF_PT_interface_temporary_windows,
     USERPREF_PT_interface_statusbar,
     USERPREF_PT_interface_translation,
+    USERPREF_PT_interface_accessibility,
     USERPREF_PT_interface_text,
     USERPREF_PT_interface_menus,
     USERPREF_PT_interface_menus_mouse_over,
diff --git a/source/blender/blenloader/intern/versioning_userdef.cc b/source/blender/blenloader/intern/versioning_userdef.cc
index 5c166c566b0..4b39bcb7153 100644
--- a/source/blender/blenloader/intern/versioning_userdef.cc
+++ b/source/blender/blenloader/intern/versioning_userdef.cc
@@ -1146,7 +1146,7 @@ void blo_do_versions_userdef(UserDef *userdef)
   }
 
   if (!USER_VERSION_ATLEAST(280, 44)) {
-    userdef->uiflag &= ~(USER_NO_MULTITOUCH_GESTURES | USER_UIFLAG_UNUSED_1);
+    userdef->uiflag &= ~USER_NO_MULTITOUCH_GESTURES;
     userdef->uiflag2 &= ~USER_UIFLAG2_UNUSED_0;
     userdef->gp_settings &= ~GP_PAINT_UNUSED_0;
   }
diff --git a/source/blender/editors/interface/interface_handlers.cc b/source/blender/editors/interface/interface_handlers.cc
index 518b06e9af2..a128fc0f7ca 100644
--- a/source/blender/editors/interface/interface_handlers.cc
+++ b/source/blender/editors/interface/interface_handlers.cc
@@ -11558,7 +11558,9 @@ static int ui_pie_handler(bContext *C, const wmEvent *event, uiPopupBlockHandle
 
         /* handle animation */
         if (!(block->pie_data.flags & UI_PIE_ANIMATION_FINISHED)) {
-          const double final_time = 0.01 * U.pie_animation_timeout;
+          const double final_time = (U.uiflag & USER_REDUCE_MOTION) ?
+                                        0.0f :
+                                        0.01 * U.pie_animation_timeout;
           float fac = duration / final_time;
           const float pie_radius = U.pie_menu_radius * UI_SCALE_FAC;
 
diff --git a/source/blender/editors/screen/area.cc b/source/blender/editors/screen/area.cc
index 40910c175ff..0767a5d30c2 100644
--- a/source/blender/editors/screen/area.cc
+++ b/source/blender/editors/screen/area.cc
@@ -2360,7 +2360,7 @@ void region_toggle_hidden(bContext *C, ARegion *region, const bool do_fade)
 
   region->flag ^= RGN_FLAG_HIDDEN;
 
-  if (do_fade && region->overlap) {
+  if (do_fade && region->overlap && !(U.uiflag & USER_REDUCE_MOTION)) {
     /* starts a timer, and in end calls the stuff below itself (region_sblend_invoke()) */
     ED_region_visibility_change_update_animated(C, area, region);
   }
diff --git a/source/blender/makesdna/DNA_userdef_types.h b/source/blender/makesdna/DNA_userdef_types.h
index eccbd221ce8..bc07eb113cf 100644
--- a/source/blender/makesdna/DNA_userdef_types.h
+++ b/source/blender/makesdna/DNA_userdef_types.h
@@ -763,7 +763,7 @@ typedef enum eWalkNavigation_Flag {
 /** #UserDef.uiflag */
 typedef enum eUserpref_UI_Flag {
   USER_NO_MULTITOUCH_GESTURES = (1 << 0),
-  USER_UIFLAG_UNUSED_1 = (1 << 1), /* cleared */
+  USER_REDUCE_MOTION = (1 << 1),
   USER_WHEELZOOMDIR = (1 << 2),
   USER_FILTERFILEEXTS = (1 << 3),
   USER_DRAWVIEWINFO = (1 << 4),
diff --git a/source/blender/makesrna/intern/rna_space.cc b/source/blender/makesrna/intern/rna_space.cc
index ba6153a0652..98a9cf756c4 100644
--- a/source/blender/makesrna/intern/rna_space.cc
+++ b/source/blender/makesrna/intern/rna_space.cc
@@ -769,7 +769,7 @@ static void rna_Space_bool_from_region_flag_update_by_type(bContext *C,
   if (region) {
     if (region_flag == RGN_FLAG_HIDDEN) {
       /* Only support animation when the area is in the current context. */
-      if (region->overlap && (area == CTX_wm_area(C))) {
+      if (region->overlap && (area == CTX_wm_area(C)) && !(U.uiflag & USER_REDUCE_MOTION)) {
         ED_region_visibility_change_update_animated(C, area, region);
       }
       else {
diff --git a/source/blender/makesrna/intern/rna_userdef.cc b/source/blender/makesrna/intern/rna_userdef.cc
index c433765ec48..3042c475f07 100644
--- a/source/blender/makesrna/intern/rna_userdef.cc
+++ b/source/blender/makesrna/intern/rna_userdef.cc
@@ -5375,6 +5375,13 @@ static void rna_def_userdef_view(BlenderRNA *brna)
       prop, nullptr, "statusbar_flag", STATUSBAR_SHOW_EXTENSIONS_UPDATES);
   RNA_def_property_ui_text(prop, "Extensions Updates", "Show Extensions Update Count");
   RNA_def_property_update(prop, NC_SPACE | ND_SPACE_INFO, "rna_userdef_update");
+
+  /* Accessibility. */
+  prop = RNA_def_property(srna, "use_reduce_motion", PROP_BOOLEAN, PROP_NONE);
+  RNA_def_property_boolean_sdna(prop, nullptr, "uiflag", USER_REDUCE_MOTION);
+  RNA_def_property_ui_text(
+      prop, "Reduce Motion", "Avoid animations and other motion effects in the interface");
+  RNA_def_property_update(prop, 0, "rna_userdef_update");
 }
 
 static void rna_def_userdef_edit(BlenderRNA *brna)
diff --git a/source/blender/windowmanager/intern/wm_operators.cc b/source/blender/windowmanager/intern/wm_operators.cc
index 1046a74b24f..966acb913ab 100644
--- a/source/blender/windowmanager/intern/wm_operators.cc
+++ b/source/blender/windowmanager/intern/wm_operators.cc
@@ -1080,7 +1080,7 @@ void WM_operator_view3d_unit_defaults(bContext *C, wmOperator *op)
 
 int WM_operator_smooth_viewtx_get(const wmOperator *op)
 {
-  return (op->flag & OP_IS_INVOKE) ? U.smooth_viewtx : 0;
+  return (op->flag & OP_IS_INVOKE && !(U.uiflag & USER_REDUCE_MOTION)) ? U.smooth_viewtx : 0;
 }
 
 wmOperatorStatus WM_menu_invoke_ex(bContext *C,