Use `bpy.ops.wm.read_homefile(use_factory_startup=True)` to load the default 'homefile'. Otherwise Blender will load the saved-as-default file, which can be quite different from the default startup file.
Use `bpy.ops.wm.read_homefile(use_factory_startup=True)` to load the default 'homefile'. Otherwise Blender will load the saved-as-default file, which can be quite different from the default startup file.