Autosave files are created from memfile undo, which doesn't save legacy mesh data. This leads to a crash on file load. In addition the mesh code can now add CustomData layers when saving files, which did not work if the original domain had no layers. In that case CustomData.layers is NULL and DNA has nothing to key off of when loading the file later. Pull Request: https://projects.blender.org/blender/blender/pulls/106648